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View Article Google Scholar 8. Knockdown of Id1 slightly decreased the proliferation of MM cell. B Expression of Id1 was checked by immunostaining. S12and partially rescued Dorsomorphin inhibition of anchorage-independent colony formation Fig. Expression plasmids of truncated Smad1-MH2 were constructed by cloning the indicated sequence into pEGFP vector using the following primers:

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Knockdown of Id1 slightly decreased the proliferation of MM cell.

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Finally, we determined the efficacy of Dorsomorphin in inhibiting in vivo tumor growth of KMM cells. Statistical analysis Data were analyzed by Student's t test. Cells were harvested at the indicated times. Sh LANA was previously reported [49]. Ids were indispensable driving forces for KSHV-induced tumorigenesis Id proteins, especially Id1, are able to promote cell proliferation and cell cycle progression.

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